Signaling to regulate FOXO1 may be the most important mechanism for
insulin to control transcription. In spite of this, little
is known about how insulin regulates FOXO1 and how
FOXO1 may contribute to insulin resistance in adipocytes, which is the
most critical cell type in the development of
insulin resistance. We report a detailed mechanistic analysis of insulin
control
of FOXO1 in human adipocytes obtained from
non-diabetic subjects and from patients with T2D.

Systems-wide
experimental and modeling analysis of insulin signaling through FOXO1 in human
adipocytes, normally and in type 2 diabetes.