CompBioMed Conference 2023 (CBMC23) will address all aspects of computational biomedicine, from genome through organ to whole human and population levels, embracing data driven, mechanistic modelling and simulation, machine learning and combinations thereof. This year Gunnar will is one of the Plenary Speakers and he will discuss physiologically based digital twins: a digital and interactive copy of yourself that follows you throughout your health journey.
Join the VPH (Virtual Physiologocal Human) summer school in Barcelona, June 5-9, 2023. This summer school includes 15 morning lectures, one honorary VPH lecture, and a lot of networking opportunities. Gunnar will talk about about the digital twins, so don’t miss it!
Last day to register is 21 of May, and you find more information HERE
M4-health and digital twins: bring a digital copy of yourself with you throughout your health journey
Keynote Lecture, Wednesday June 7th, 2023, 09:30-11:00
Abstract: For the last 20 years, Cedersund has developed mechanistic mathematical models for all of the main organs in the human body: heart, liver, fat, brain, etc. Lately, these models have combined into an interconnected model for the body as a whole. This interconnected model can be made specifically for each individual, and is then called a digital twin. This digital twin technology employs a hybrid approach, which combines the mechanistic simulation models with machine learning and bioinformatics models. This allows a patient, doctor, or other end-user to look inside the body of a patient, as it is now, ranging from the whole-body to the intracellular level. This also allows for simulations of different future scenarios, ranging from ms to years, and can simulate e.g. the risk of a stroke, depending on choice of diets, exercise, and certain medications. The models are thus of an M4-nature: multi-level, multi-timescale, mechanistic, and multi-organ. The focus on this talk will be on how we systematically test mechanistically hypothesis on the intracellular and organ levels, using mechanistic modelling, optimization, and predictions with uncertainty – followed by corresponding model-designed experiments. I will also to some extent go through how we assemble the different organ sub-models together into the integrated digital twin, which in itself is a modelling problem, and how we then put all of this into a series of different eHealth apps.
Biosketche: Gunnar Cedersund (https://liu.se/en/employee/gunce57) heads a cross-disciplinary research group at the Department of Biomedical Engineering (IMT) at Linköping University. The heart of this group (15+ people) does hybrid mathematical modelling, combining machine learning with mechanistic small- and large-scale models. These models are developed using both pre-clinical and experimental data of various types, which are collected both by experimentalists and clininicians within the same group, and by numerous collaborators. These models are made available for preventive and patient-centric care, as well as for drug development and medical pedagogics, using innovative eHealth technologies. This is made possible, e.g., via the fact that Cedersund heads the 6MEuro EU project STRATIF-AI, which brings his digital twins into healthcare for all phases of stroke (prevention, acute treatment, and rehabilitation), using a series of different apps, which all are connected to the same backend.
BME@LiU 2023 is a conference day filled with activities to highlight the research conducted at Linköping University (LiU) in the field of biomedical engineering (BME).
Biomedical Engineering, or MedTech, lies at the intersection of many of LiUs strength and strategic areas. It involves development of state-of-the-art technologies such as biosensors, medical imaging, AI, eHealth, visualization, with many applications in Life Sciences, e.g. circulatory and metabolic diseases, inflammation, neurological diseases and cancer.
BME@LiU is a day filled with activities related to the field of biomedical engineering. From invited and contributed talks, to posters, exhibitions, and mingling. These activities reach out to all researchers, companies, organizations, students and clinicians who support, contribute to, or utilize BME technologies.
If you would like to have an oral presentation, submit abstracts before March 27
We are pleased to invite you to our fourth Workshop on Modelling in Biology and Medicine (MBM 2023) on the 15-17th of May. We aim to gather all young researchers in Sweden working on modelling of biological systems. Our ambition is to give all participating PhD students and Postdocs the opportunity to present their work through an oral presentation or a poster. Further, we wish to provide an insight into how modelling in biology and medicine is practiced in academia and industry.
The workshop will be held in both plenary presentation sessions for larger talks as well as in smaller sessions for e.g. poster presentations. You can participate at MBM 2023 by
giving a plenary talk,
presenting a poster
or simply as an observer
The workshop will be in-person at Linköping University, Campus US.
When: 15-17th of May 2023 Where: Linköping
Why: Bringing together young researchers in Sweden working on the border of mathematics, biology, and medicine
The opening ceremony of the Virtual Physiological Human (VPH) conference was something special, it featured a lecture-performance with our physiologically based dancing digital twins. The VPH Institute has now published a news letter were you can read more about the development of the digital twins for the past 20 years, and more about the future visions for using them within biomedical teaching and patient-centric care.
“Take your digital twin with you throughout your health journey: from dance performances to patient-centric, preventive healthcare” For link click HERE
The 21st International Conference on Systems Biology (ICSB 2022) was held in Berlin, Germany, these past few days. We had a great time there and had the opportunity to meet great people, take part in interesting discussions, and see some of Berlin. During the conference, we presented several posters and gave some talks (summarized below). We would like to extend our thanks to the ICSB committee for a well-organized conference. Until next time, from the ISB group.
M4-health: digital twins that follow you throughout your health journey, Gunnar Cedersund
Authors: Gunnar Cedersund
An interconnected multi-level mechanistic model of the human brain, Nicolas Sundqvist
Authors: Nicolas Sundqvist, Henrik Podéus, Malin Ejneby Silverå, Sebastian Sten, Salvador Dura-Bernal, Soroush Safaei, Maria Engström and Gunnar Cedersund
Digital twins and hybrid modelling for simulation of physiological variables and stroke risk, Tilda Herrgårdh
Authors: Tilda Herrgårdh, Elizabeth Hunter, Kajsa Tunedal, John D. Kelleher and Gunnar Cedersund
Insights on hemodynamic changes in hypertension and T2D through non-invasive cardiovascular modeling, Kajsa Tunedal
Authors: Kajsa Tunedal, Carl-Johan Carlhäll, Federica Viola, Tino Ebbers and Gunnar Cedersund
Mathematical modeling of cytokine interplay in human monocytes during LPS stimulation, Niloofar Nikaein
Authors: Niloofar Nikaein, Kedeye Tuerxun, Daniel Eklund, Alexander Persson, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Gunnar Cedersund, Elin Nyman, Dirk Repsilber and On Behalf Of The X-Hide Consortium
Connecting the Neurovascular coupling and Electrophysiological signaling – a modeling approach, Henrik Podéus
Authors: Henrik Podéus, Gunnar Cedersund and Salvador Dura-Bernal
An in silico resection to estimate global and regional hepatobiliary function in patients undergoing hepatectomy, Christian Simonsson
Authors: Christian Simonsson, Wolf Claus Bartholomä, Anna Lindhoff Larsson, Markus Karlsson, Bengt Norén, Gunnar Cedersund, Nils Dahlström, Per Sandström and Peter Lundberg
A comprehensive mechanistic model of adipocyte signaling with layers of confidence, William Lövfors
Authors: William Lövfors, Cecilia Jönsson, Charlotta S. Olofsson, Gunnar Cedersund and Elin Nyman
In the middle of July, Kajsa Tunedal went to Glasgow to attend the IEE Engineering in Medicine and Biology Conference (EMBC) (https://embc.embs.org/2022/) and presented an ePoster: “Insights of Hemodynamic Changes in Hypertension and Diabetes through a 4D Flow MRI-Based Personalized Cardiovascular Model”. It was a great experience starting with a very scottish opening ceremony and followed by many interesting talks, workshops, and meetings with other modellers and researchers with interests in cardiovascular mechanisms and measurements.