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The ISBGroup Blog

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Here you can read about everything that's happening in the ISB Group.

A Recap of the Latest STRATIF-AI Meeting

Uncategorised Posted on Thu, May 16, 2024 18:13:12

On April 11-12, we had a new bi-yearly meeting in STRATIF-AI. This meeting was held in beautiful Nottwil, Switzerland, where the Swiss Paraplegic Research center (SPF) is situated.  SPF is responsible for the work with policy and actions toward stakeholders to achieve ultimate clinical implementation, and they were also the hosts of this event.

We have these events every 6 months, and they serve both the purpose of team building and increased understanding of each others’ perspectives and serve to help us focus on the most urgent and timely topics. This time we focused primarily on the design of the 6 clinical studies, which ethical applications were to be submitted at the end of that month. Four of these studies are dedicated to the collection of patient data, aimed at training both the machine learning algorithms and the mechanistic aspects of digital twins. The remaining two studies focus on the real-world testing of eHealth apps within clinical settings. The largest of those will test whether the digital twin improves clinical health conversations, in 300 patients, compared with 300 matched controls.

Overall, the meeting was a success, and we have now passed the planning phase of the project, with requirement specifications and ethical plans, and are now moving into action: into prototype development of the apps, and towards the first pilot studies. 



CompBioMed Conference 2023: Munich, 12-14 September

Uncategorised Posted on Tue, April 11, 2023 08:58:00

CompBioMed Conference 2023 (CBMC23) will address all aspects of computational biomedicine, from genome through organ to whole human and population levels, embracing data driven, mechanistic modelling and simulation, machine learning and combinations thereof. This year Gunnar will is one of the Plenary Speakers and he will discuss physiologically based digital twins: a digital and interactive copy of yourself that follows you throughout your health journey.

You can read more about it HERE



Keynote lecture at the 7th VPH Summer School – Barcelona, June 5-9, 2023

Uncategorised Posted on Tue, April 04, 2023 07:33:00

Join the VPH (Virtual Physiologocal Human) summer school in Barcelona, June 5-9, 2023. This summer school includes 15 morning lectures, one honorary VPH lecture, and a lot of networking opportunities. Gunnar will talk about about the digital twins, so don’t miss it!

Last day to register is 21 of May, and you find more information HERE


M4-health and digital twins: bring a digital copy of yourself with you throughout your health journey 

Keynote Lecture, Wednesday June 7th, 2023, 09:30-11:00

Abstract: For the last 20 years, Cedersund has developed mechanistic mathematical models for all of the main organs in the human body: heart, liver, fat, brain, etc. Lately, these models have combined into an interconnected model for the body as a whole. This interconnected model can be made specifically for each individual, and is then called a digital twin. This digital twin technology employs a hybrid approach, which combines the mechanistic simulation models with machine learning and bioinformatics models. This allows a patient, doctor, or other end-user to look inside the body of a patient, as it is now, ranging from the whole-body to the intracellular level. This also allows for simulations of different future scenarios, ranging from ms to years, and can simulate e.g. the risk of a stroke, depending on choice of diets, exercise, and certain medications. The models are thus of an M4-nature: multi-level, multi-timescale, mechanistic, and multi-organ. The focus on this talk will be on how we systematically test mechanistically hypothesis on the intracellular and organ levels, using mechanistic modelling, optimization, and predictions with uncertainty – followed by corresponding model-designed experiments. I will also to some extent go through how we assemble the different organ sub-models together into the integrated digital twin, which in itself is a modelling problem, and how we then put all of this into a series of different eHealth apps.

BiosketcheGunnar Cedersund (https://liu.se/en/employee/gunce57) heads a cross-disciplinary research group at the Department of Biomedical Engineering (IMT) at Linköping University. The heart of this group (15+ people) does hybrid mathematical modelling, combining machine learning with mechanistic small- and large-scale models. These models are developed using both pre-clinical and experimental data of various types, which are collected both by experimentalists and clininicians within the same group, and by numerous collaborators. These models are made available for preventive and patient-centric care, as well as for drug development and medical pedagogics, using innovative eHealth technologies. This is made possible, e.g., via the fact that Cedersund heads the 6MEuro EU project STRATIF-AI, which brings his digital twins into healthcare for all phases of stroke (prevention, acute treatment, and rehabilitation), using a series of different apps, which all are connected to the same backend.



BME@LiU 2023 – Register Now

Uncategorised Posted on Mon, March 20, 2023 07:00:00

BME@LiU 2023 is a conference day filled with activities to highlight the research conducted at Linköping University (LiU) in the field of biomedical engineering (BME).

Biomedical Engineering, or MedTech, lies at the intersection of many of LiUs strength and strategic areas. It involves development of state-of-the-art technologies such as biosensors, medical imaging, AI, eHealth, visualization, with many applications in Life Sciences, e.g. circulatory and metabolic diseases, inflammation, neurological diseases and cancer.

BME@LiU is a day filled with activities related to the field of biomedical engineering. From invited and contributed talks, to posters, exhibitions, and mingling. These activities reach out to all researchers, companies, organizations, students and clinicians who support, contribute to, or utilize BME technologies.

If you would like to have an oral presentation, submit abstracts before March 27

BME@LiU 2023

When: April 20, 08.30 – 17.00

Where: Norra Entrén, Campus US and via Zoom

Read more and register here https://liu.se/en/research/bme-conference-2023



Sign up: Workshop on Modelling in Biology and Medicine (MBM 2023)

Uncategorised Posted on Tue, March 07, 2023 13:39:24

Welcome to MBM 2023!  

We are pleased to invite you to our fourth Workshop on Modelling in Biology and Medicine (MBM 2023) on the 15-17th of May.  We aim to gather all young researchers in Sweden working on modelling of biological systems. Our ambition is to give all participating PhD students and Postdocs the opportunity to present their work through an oral presentation or a poster. Further, we wish to provide an insight into how modelling in biology and medicine is practiced in academia and industry.  

The workshop will be held in both plenary presentation sessions for larger talks as well as in smaller sessions for e.g. poster presentations. You can participate at MBM 2023 by  

  • giving a plenary talk,  
  • presenting a poster   
  • or simply as an observer  

The workshop will be in-person at Linköping University, Campus US. 

When: 15-17th of May 2023  
Where: Linköping 

Why: Bringing together young researchers in Sweden working on the border of mathematics, biology, and medicine  

How: Oral presentation, poster, or as an observer  
Abstract submission: https://forms.gle/jHNrg1QM6bGQhmx9A, deadline 14th of April 
Register: Registration will open soon 

More informationhttps://mbm.systemsbiology.se/   



VPH News Letter – Dancing digital twins

Uncategorised Posted on Mon, October 17, 2022 09:00:00

The opening ceremony of the Virtual Physiological Human (VPH) conference was something special, it featured a lecture-performance with our physiologically based dancing digital twins. The VPH Institute has now published a news letter were you can read more about the development of the digital twins for the past 20 years, and more about the future visions for using them within biomedical teaching and patient-centric care.

Take your digital twin with you throughout your health journey: from dance performances to patient-centric, preventive healthcare” For link click HERE



ICSB 2022

Uncategorised Posted on Mon, October 10, 2022 09:59:46

The 21st International Conference on Systems Biology (ICSB 2022) was held in Berlin, Germany, these past few days. We had a great time there and had the opportunity to meet great people, take part in interesting discussions, and see some of Berlin. During the conference, we presented several posters and gave some talks (summarized below). We would like to extend our thanks to the ICSB committee for a well-organized conference. Until next time, from the ISB group.

The full program can be found here: https://www.icsb2022.berlin/, and down below is a summary of our contributions.

M4-health: digital twins that follow you throughout your health journey, Gunnar Cedersund

Authors: Gunnar Cedersund

An interconnected multi-level mechanistic model of the human brain, Nicolas Sundqvist

Authors: Nicolas Sundqvist, Henrik Podéus, Malin Ejneby Silverå, Sebastian Sten, Salvador Dura-Bernal, Soroush Safaei, Maria Engström and Gunnar Cedersund

Digital twins and hybrid modelling for simulation of physiological variables and stroke risk, Tilda Herrgårdh

Authors: Tilda Herrgårdh, Elizabeth Hunter, Kajsa Tunedal, John D. Kelleher and Gunnar Cedersund

Insights on hemodynamic changes in hypertension and T2D through non-invasive cardiovascular modeling, Kajsa Tunedal

Authors: Kajsa Tunedal, Carl-Johan Carlhäll, Federica Viola, Tino Ebbers and Gunnar Cedersund

Mathematical modeling of cytokine interplay in human monocytes during LPS stimulation, Niloofar Nikaein

Authors: Niloofar Nikaein, Kedeye Tuerxun, Daniel Eklund, Alexander Persson, Robert Kruse, Eva Särndahl, Eewa Nånberg, Antje Thonig, Gunnar Cedersund, Elin Nyman, Dirk Repsilber and On Behalf Of The X-Hide Consortium

Connecting the Neurovascular coupling and Electrophysiological signaling – a modeling approach, Henrik Podéus

Authors: Henrik Podéus, Gunnar Cedersund and Salvador Dura-Bernal

An in silico resection to estimate global and regional hepatobiliary function in patients undergoing hepatectomy, Christian Simonsson

Authors: Christian Simonsson, Wolf Claus Bartholomä, Anna Lindhoff Larsson, Markus Karlsson, Bengt Norén, Gunnar Cedersund, Nils Dahlström, Per Sandström and Peter Lundberg

A comprehensive mechanistic model of adipocyte signaling with layers of confidence, William Lövfors

Authors: William Lövfors, Cecilia Jönsson, Charlotta S. Olofsson, Gunnar Cedersund and Elin Nyman



VPH 2022 – Less than 2 weeks to the conference! 6-9 September, Porto, Portugal  

Uncategorised Posted on Thu, August 25, 2022 16:41:59

Dont miss the chance to meet us at The Virtual Physiologiacl Human Conference 2022!

We have three presentations and our digital twin will be a part of the welcome reception

Dancing Digital Twins performance

Welcome reception, 7th September, 19:30 Auditorium

Unique collaboration between the Swedish researcher and pianist Gunnar Cedersund and choreographer and dancer Julia Bengtsson fuses digital twin technology and visualization with dance and music

Nicolas Sundqvist

Presentation, 8th September

Session 14: Multiscale modelling. 8.30-10.30, Room 2

An interconnected multi-level mechanistic model of the human brain

Oscar Arrestam

Presentation, 9th September

Session 22: Computational modeling in health and disease 4. 8.45-10.15 Room 2

Digital twin predicting diet response before and after long-term fasting (see poster below)

Gunnar Cedersund

Presentation, 9th September

Session 25: Computational tools and simulation in biomechanics 4

10.30-12.30 Auditorium

M4-health: digital twins that follow you throughout your health journey



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