We recently attended the International Study Group for Systems Biology (ISGSB) 2022 conference where we gave two talks. Our first talk was given by Gunnar Cedersund and was on how we can use M4-models and digital twin tools to help patients on their health journey throughout various aspects of their lives. The second talk was given by Nicolas Sundqvist and was on our efforts to develop an interconnected multi-level mechanistic model of the human brain. The conference was a success as we partook in interesting discussions and offered our contributions to the ISGSB community. On another fun note, our poster designed and presented by Nicolas Sundqvist was voted joint best poster of the conference. We are looking forward to the next iteration of the ISGSB conference.