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The ISBGroup Blog

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Here you can read about everything that's happening in the ISB Group.

The IEE Engineering in Medicine and Biology Conference (EMBC)

Events Posted on Mon, August 22, 2022 07:00:00

In the middle of July, Kajsa Tunedal went to Glasgow to attend the IEE Engineering in Medicine and Biology Conference (EMBC) (https://embc.embs.org/2022/) and presented an ePoster: “Insights of Hemodynamic Changes in Hypertension and Diabetes through a 4D Flow MRI-Based Personalized Cardiovascular Model”. It was a great experience starting with a very scottish opening ceremony and followed by many interesting talks, workshops, and meetings with other modellers and researchers with interests in cardiovascular mechanisms and measurements.

Kajsa Tundedal showing her poster at the IEE Engineering in Medicine and Biology Conference
Opening cermony at the EMBC conference


New article in PLoS Computational Biology

News, Systems biology and science Posted on Mon, May 02, 2022 07:00:00

Sundqvist N, Grankvist N, Watrous J, Mohit J, Nilsson R, Cedersund G. Validation-based model selection for 13C metabolic flux analysis with uncertain measurement errors. PLoS Comput Biol. 2022 Apr 11;18(4):e1009999. doi: 10.1371/journal.pcbi.1009999

Author summary: Measuring metabolic reaction fluxes in living cells is difficult, yet important. The gold standard is to label extracellular metabolites with 13C, to use mass spectrometry to find out where the 13C-atoms ends up, and finally use mathematical modelling to calculate how quickly each reaction must have flowed, for the 13C-atoms to end up like that. This measurement thus relies on usage of the right mathematical model, which must be selected among various candidate models. In this manuscript, we present a new way to do this model selection step, utilizing validation data. Using an adopted approach to calculate the uncertainty of model predictions, we identify new validation experiments, which are neither too similar, nor too dissimilar, compared to the previous training data. The model candidate that is best at predicting this new validation data is the one chosen. Tests on simulated data where the true model is known, shows that the validation-based method is robust when the magnitude of the error in the measurement uncertainty is unknown, something that conventional methods are not. This improvement is important since true uncertainties can be difficult to estimate for these data. Finally, we demonstrate how the new method can be used on real data, to identify fluxes and important reactions.



Dancing Digital Twins – Seeing the music of Chopin and and Beethoven

Events Posted on Wed, April 27, 2022 23:00:44

After many years of preparations – 20+ years of developing the digital twins in general, and now 3-4 years of making them dance – the first lecture-performance is at last about to take place. On Thursday at 17.00 it happens! In this highly innovative event, you will not only be able to see with your eyes what happens in some of the best music ever written, but also be able to see inside a computer copy of some people in the audience – into their digital twins. By looking at and inside these digital twins, we will together explore what happens both in the body when you dance, and in the music that your twins are dancing to.

Does it sound intriguing?

Then come to Berzeliussalen at Linköping University, Campus US, on April 28, at 17-17.45. Welcome!

Read more about the event here



In News: Say hello to your digital twin

News Posted on Thu, April 21, 2022 07:00:00

An article about the Digital Twin Technology has been published in the latest issue of LiU Magazine.

Säg hej till din digitala tvilling (LIU MAGASIN NUMMER ETT 2022, s16-17)

The online version (In Swedish only) can be found here.



Last day to register: BME@LiU 2022

Events Posted on Thu, April 14, 2022 07:00:00

Today is the last day to register to the Biomedical Engineering conference at Linköping University the 28th of April, BME@LiU 2022.

Don’t miss the chance to see cool examples of combination between technology and medicine. You will be able to meet companies, researchers, and students. Get inspired, learn more about cutting-edge research, and why not discuss new collaborations. The conference will be held at Campus US, but you can also join us online.

For more information about the conference click here.

To register click here.

Contact: bme.at.liu@imt.liu.se



28th of April: A Biomedical Engineering conference at Linköping University

Events Posted on Tue, April 12, 2022 07:00:00

The Biomedical Engineering conference at Linköping University BME@LiU 2022 is a day filled with activities related to the field of Biomedical Engineering. The conference reaches out to researchers, companies, and organizations, who support, contribute to, or utilize Biomedical Engineering Technologies. This involves development of state-of-the-art technologies such as biosensors, medical imaging, AI, eHealth, visualization, with many applications in Life Sciences, e.g., circulatory and metabolic diseases, inflammation, neurological diseases and cancer.

BME@LiU 2022 will offer several levels of engagement: invited and contributed talks, posters, exhibitions, mingling arenas, and a dinner.

Details

When? April 28, 08.00 – 17.00

Where? Campus US at LiU and online

Last date to register: April 14 2022. To register, click here

More information about the conference can be found here.

Contact: bme.at.liu@imt.liu.se

Keynote speakers:

Torbjörn Kronander, CEO Sectra

Jessica C. Ramella-Roman, Dr/Associate professor at the Medical Photonics Laboratory

Lena Miranda, CEO Linköping Science Park

Gerhard Andersson, Professor at the Department of Behavioural Sciences and Learning (IBL)



Uncategorised Posted on Mon, June 14, 2021 11:36:20

Nu är programmet för Almedalen ute, och vi kommer att dyka upp i diskussioner kring den Digitala Tvillingen på måndag den 5 juli kl 13.15-14.00. Missa inte! Konferensen är digital så du kan se den bekvämt hemifrån soffan.

https://eastsweden.se/almedalen



Programmer wanted!

Uncategorised Posted on Tue, May 25, 2021 11:30:31

We are looking for a programmer to work on the interface for the digital twin project. Please spread to anyone you think would be a good match!

Ansök här / Apply here

Here is a short film about the Digital Twin project.

Our work with the new digital twin technology – an interactive computer model, describing the multi-organ, and multi-timescale biochemistry and physiology of a specific person – has now led to a first prototype which is almost ready to be tested in a clinical environment. However, to be able to do that, we need to have suitable user interface, and this is where you come in!

In english:

“We are looking for someone experienced in working with programming, visualisation, software architecture, and user friendliness. Submitting a sample of previous work with you application will increase your chances, in particular apps and software projects that includes visualisation. You are interested in design and you are an attentive listener who can work in a group setting to interpret the best solution to what researchers, clinical personnel and private users need.

Your tasks will primarily be development of the front-end software for research and clinical environments, focusing on visualisation and app-design. ISB group at IMT have developed a so called Digital Twin, computer model copies of a patient, which will function as support for the Health Conversation. We have a few previously developed prototypes, but now we need someone to help us make a version with a user interface suitable for testing in clinical studies. You will work mostly with the coding of the software, but some design and user interaction and evaluation is also included.”

På svenska:

“Vi söker nu någon som har erfarenhet av att arbeta med programmering, visualisering, mjukvaruarkitetktur och användarvänlighet.  Tidigare arbetsprov av egna utvecklade appar och andra mjukvaruprojekt, speciellt sådana som inkluderar en visualiseringskomponent, är en viktig del av bedömningen. Du är antagligen intresserad av design och en god lyssnare som kan arbeta i grupp och tolka vad både forskare, vårdpersonal och privata användare behöver. 

Dina arbetsuppgifter kommer bestå i framför allt arbete med att utveckla front-end mjukvara för en vetenskaplig och klinisk miljö, med fokus på visualisering och app-design. I ISB-group på IMT har vi utvecklat en så kallad Digital Tvilling, datorkopior av en patient, som ska fungera som stöd i vårdens hälsosamtal. Vi har tidigare utvecklat ett par prototyper, men behöver nu någon som gör en första mer färdig version av användargränssnittet att testa i kliniska studier.  Du kommer att arbeta mycket med själva kodningen av mjukvaran, men en del design och användarinteraktion ingår också. “

If you have any questions, please contact Karin Lundengård at karin.lundengard@liu.se



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