Today, parts of the group participated at a seminar day with the Swedish 3R center in stockholm, both with posters, presentations and in discussions.
The day consisted of presentations from people doing research that can/could lead to replacement of animal testing – specifically on organs on a chip and mathematical modelling – and a panel discussions. In the panel discussions, among other things, the capabilities of the presented research to replace animal testing was discussed, what they can replace, and what the hurdels of making that happen are. All in all, the day gave a clearer vision on where we are, where we couldget, and how to do it.
From the panel discussion. From left to right, Per Artursson, Uppsala University, Karin Stenkula, Lund University, Lotte Martoft, AstraZeneca, Peter Gennemark, AstraZeneca, and Gunnar Cedersund chairing the discussions.
Elin has received two substantial grants, from the Swedish Research Council (VR) and from the Center for Industrial Information Technology (CENIIT). Both grants are given to young and promising researchers.
VR-NT From omics to patient specific simulations (950 000 SEK per year for 4 years) CENIIT Executable models for drug development (450 000 SEK per year for up to 6 years)
During 7th and 8th of the November, we have had meeting with our partners in the PRECISE4Q project here in Linköping. In PRECISE4Q, we are working wit developing hybrid models for a decision support for Stroke treatment together with scientists within health informatics, computer science, machine learning, medicine, etc.
During the meetings, we discussed our upcoming EU review (we are financed by EUs Horizon 2020 project), how we should move forward in general, and met with local scientists here in Linköping that are working with similar things.
Today, Therese Alenvret presented here master thesis on how health information from the clinic and/or different mobile devices can be retrieved and modeled to be used by our digital twin. So now we now more about the posibilities and challanges with accessing personal data to the digital twin. Good job Therese!
With the summer long gone, and a new term in full swing, it is time for a very late and past-due update post! The autumn of 2019 was hectic, exciting and rewarding! The year started off with the addition of three new group members, two PhDs and a post-doc (more about this further down). We also started our to date most collaborative effort, which was to connect (almost) all of our existing models. The first phase of this project culminated in a fully packed event at the Almedalen week in the beginning of the summer, but more about this in a later blog post.
The group has grown. We have had several new (but old) additions. Both me (Christian Simonsson) and Nicolas Sundqvist, both previous master-thesis students in systems biology, started PhD-positions in the group. Here’s a short update from us. I’m finishing up my projects concerning the metabolic syndrome and I have just started new projects concerning disease progression in the liver (ASH/NASH). Adding to this, I will spend half of my PhD working at the Division of Radiological Sciences (RAD) in the group of Peter Lundberg, doing clinical research. Right now, I am analyzing MRE data for patients with suspected liver fibrosis. Nicolas is continuing his work with metabolic flux modelling, but he has also branched out, and is now doing modelling of fMRI data and brain metabolism in the group of Maria Engstrom. Also, Belen Casas is doing her post-doc in our group. Her post-doc project concerns mechanistic modeling of MPS-systems.
Three talented internship-students have just ended their one year stay with us. Kajsa Tunedal has worked with several projects, including modelling of NEFA circulation and uptake in the liver, and modelling of cortisol levels in relation to stress. Henrik Podéus has worked with connecting several models describing the different aspects of the neurovascular coupling in collaboration with Sebastian Sten (PhD in Maria Engstroms group). Anton Tornerefelt has with collaborators from Örebro’s University created a model of Macrophages activation. You all have done great work and we wish you the best of luck in all your future endeavors!
Here is two of our latest group photos! The latter is from our latest group
retreat, which took place at the beautiful Omberg eco-park.
Two exciting days of biomedical engineering just ended after our division hosted the annual MTD conference. The purpose of MTD is to be the most important meeting place for medical technology in Sweden. Where all key stakeholders; researchers, company representatives and medical experts can meet and discuss important questions. Our presence was at the digitalization of healthcare track where our PI, Gunnar, held the opening talk. He presented our group vision of personalized medicine: digital twins – physiologically based, personalized, simulation models to be used in healthcare. Also, Elin and Tilda each had poster presentations representing modelling research. All in all, two good days where we could showcase our research vision to the Swedish biomedical community.
Hello,
my name is Antonia and I’m the new intern in the ISB group. My research project
is about the dietary effects on acute and chronic inflammation in the human
liver, and also how exercise and muscle growth is affected by switching diets.
The state of the liver is strongly associated with both physical activity and
your dietary habits, therefore it’s quite relevant to look at these two factors
and how they could affect the liver. My focus will be on the switching from an
omnivore to a strict plant-based diet. Since I’m vegan myself, I thought it
would be interesting to do a project that is connected to my lifestyle. I’m
planning on working on this project throughout the whole year and I’m excited
to see how it goes!
This week we are going to Medicinteknikdagarna – a conference for medical engineering here in Linköping (at Konsert & kongress). We have a presentation on Wednesday 13:30 and we have two posters. We will also be present in the LiU monter. The poster session and LiU monter is open for the public. Hope to see you there!
