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Here you can read about everything that's happening in the ISB Group.

Two widely different workshops in one day: oncogenetics and online gaming

Events, News Posted on Sat, November 22, 2025 19:22:52

I always loved to go from one community to another, and to build bridges and see connections between things that may seem unrelated, to some even unconnectable or irreconcilable. This Thursday, I had a day that manifested that in a fun way: by attending, and actively engaging with, two completely different workshops.

The first workshop was the annual Swedish meeting on oncogenetics (program below). Oncogenetics means that study or clinical diagnosis of cancer risks based on genetic factors. Since genetics is a strong risk factor for many cancer types, this is an important, although quite recent, clinical domain, and most regions nowadays have such clinics. At this workshop, I gave the final lecture before lunch, and talked about how digital twins can be utilized in lifestyle changes. Lifestyle changes had come up several times earlier in the morning, since underlying genetics just give a predisposition to cancer. In other words, lifestyle factors – like smoking, diet, exercise, weight, etc – add or subtract substantially from the basic genetic risk score. Therefore, lifestyle interventions are an important part of what clinicians in oncogenetic clinics talk to their patients about, and this is where our digital twins can come in. I mentioned our commonly presented example of using our twins to explain how you can lose or gain weight by changing your diet, and how weight and other altered risk factors enter into a risk model for stroke. In the same way, we could use those same simulated risk factors, and add them into a risk model for various cancer forms – and do the same simulations and interventions that we do for stroke e.g. in our EU-project STRATIF-AI.

This is me, just before my presentation, at the Swedish National workshop on Oncogenetics.

Extract from the program on the first workshop, arranged by the Swedish society for medical genetics and genomics.

After my presentation, and after lunch, I went over to the other event I was to visit that day: the East Sweden Game Summit. This is an annual event, which is arranged by the East Sweden Game society (ESG), which is a meeting place for companies, students, scientists, designers, etc interested in gaming. The audience here is completely different to the first one, but my digital twins fit naturally in here as well. In fact, the visualization of my digital twins is done in the software Unreal Engine, which is an engine for precisely that: game development. Therefore, there was a lot of competence at this event that I am very interested in networking with, to get our visualization module to the next level. This led to some business meetings being set up already next week on this topic, and to the preliminary joining of both ESG and at least one of its companies to our newly started excellence cluster M4-HEALTH. (More on that exciting network in later posts!) Apart from this, I also had lots of interesting conversations on design and animations over dinner, where I also started to sell in an old idea of mine: to have your digital twin also enter into the games that you play, to allow you to learn about, and also work with, your health, while you play online computer games.

This is part of the overall vision of building up an eco-system for health, where you work with your health not only when you are forced to go to the doctor because something has gone wrong, but where your health is an ongoing dialogue between you, your digital twin, your body, and your future selves, no matter what you do: go to school, go to the gym, to the supermarket – or play a video game. That ongoing dialogue with your own health in a new eco-system for health is exactly the vision of the new excellence cluster M4-HEALTH.

Me arriving to the East Sweden Game Summit. During the day, there were lectures and an exhibition. The best thing for me, however, was the dinner in the evening, where I made some very valuable connections, regarding visualization and usage of my twins using gaming technologies.

The gaming industry has been a steadily growing industry for 20+ years, regardless of pandemics, financial crashes, etc. Here is one chart to illustrate this. Charts for our local region are even more impressive: it has grown from a basically non-existing industry prior to ESG in 2017, to now a well-established sector, with ~50+ companies and 100+ employees.

This is the top 10 list of most sold games right now. As you can see, Sweden is dominating this billion dollar industry, with 5 games among the top 10 most sold games.



Digital Twins at Kvalitetsmässan – On a mission to advance effeciency in public services

Events, News Posted on Mon, November 17, 2025 12:59:00

In November 2025 Gunnar Cedersund and Maria-Anna Sotiropoulou presented the Digital Twins at Kvalitetsmässan (Quality Fair Conference) – an annual three-day event that brings together professionals from municipal, regional and government sectors to focus on advancing quality and efficiency in public services. As the Digital Twins have the potential to revolutionize various industries, particularly in municipal and regional planning, Gunnar and Maria-Anna’s presentation contributed with important insights.

Maria-Anna demonstrated how Digital Twins are being integrated into various sectors of society. For example, Norlandia, with whom we shared a booth at Kvalitetsmässan’s exhibition, is currently utilizing the Digital Twin technology to monitor and better understand the health and well-being of their employees. Looking ahead, they plan to extend this technology to enhance patient care, creating virtual models of individual patients to improve personalized healthcare management and optimize treatment plans.

Held since 1989, the fair provides a platform for in-depth discussions, international perspectives and debates on pressing social issues. It serves as an inspiring space for innovation, business development and the introduction of new smart welfare services. The fair aims to foster an environment where knowledge exchange leads to practical tools and insights for improving public sector services.

Measuring blood pressure to feed real-time data into the digital twin model.



Hälsoresan – How we will improve health state of 2400 employees at Norlandia Äldreomsorg

Events, News Posted on Fri, November 14, 2025 16:56:00

In the autumn of 2025, the Lev Skönare team (an enterprise run by the ISB Group) was invited to Norlandia Elder Care’s annual management conference to present our concept. We are now launching Hälsoresan (“Health Journey“) – a development project for approximately 2,400 employees of Norlandia Äldreomsorg – for the first time with digital support and AI.

Norlandia is the first in the world to offer all employees a digital health twin, developed by Associate Professor Gunnar Cedersund at Linköping University. The twin collects and visualizes health data on organs, metabolism, and the immune system, linked to lifestyle, and inspires small, sustainable changes based on scientific evidence.

During the conference, we demonstrated the app and the project plan, emphasizing that all personal data is fully protected and only anonymized summaries can be viewed by the company.

Discussions with managers were important: some were cautiously skeptical, while others welcomed the focus on small, everyday health habits such as walking, gradual changes in diet and exercise, and long-term sustainability. The goal is to give all employees the opportunity, step by step, to have more energy, feel joy, and foster well-being in their everyday lives.

The Lev Skönare team met with Norlandia’s approximately 60 managers to kick off Hälsoresan. Photo: Mats Janson


5 lectures in 25 hours – new record

Uncategorised Posted on Sun, October 26, 2025 23:00:51

There is a big demand to hear about our digital twins these days. Almost every week, we have been invited to give a lecture in some event, somewhere in the world. And some weeks more than one. In fact, last week, a new record was reached: 5 presentations in 25h! Here is a short description of the five presentations:

1 – Oct 14, 13.15-13.45: Joint presentation with Johan Holmsäter at Holistal’s event Health HUB. This was together with some of the most prominent health leaders in Sweden. Johan Holmsäter started the 500 000 people strong health organization Friskis & Svettis, and is arguably the single person that has made the biggest impact for the health and healthy habits in Sweden. Other important presenters were Birgitta Thörn (CEO of Holistal, and founder of e.g. the gym & health chain Itrim), Göran Adlén (the “aging backwards” guy, and a great lecturer), Anders Rosengren (a Swedish MD with lots of interesting ideas about the mentality of health, and the founder of the successful online tool Livsstilsverktyget), etc. You can read more about the event here, and at these two previous blog posts: post by me, post by Katja.

From the final panel debate. You see Johan Holmsäter to the right in an armchair, Göran Adlén to the left on stage, and Anders Rosengren to the right, also on stage.

2 – Oct 15, 10-12: General rehersal at Norlandia, in the DN house, for the big launch event of our digital twin app, to be held the week after. I had a presentation of ~25 min prepared, where I present how our multi-level and multi-organ digital twin for individuals will enter into an eHealth app, that will be given to all 3000 employees at Norlandia. More about the actual launch event (which was held on Oct 23), will come in a separate blog post.

3 – Oct 15, 12.50-13.20: Pod cast with Cambio, at the big Cambio Connect event. This podcast was broadcasted live for all attendees in the event, over lunch, and will also be sent out later in the autumn to around 1500 health care personnel.

Me, just before the podcast, with the preceding podcast behind me.

4 – Oct 15, 13.35-13.55 Presentation at the final workshop of MeDigit, a VINNOVA financed project on medical digital twins. I held this presentation online, from a corner in one of the corridors. The minute I was finished, some staff came up to me, and said that I had to “mic up” for the next presentation 🙂

5 – Oct 15, 14.20-14.35 Presentation and panel debate at the big stage at the Cambio Connect event. This was part of the last session, on AI, and wrapped up my crazy 25 hours of presentations, presentations, presentations! After this, it was time to relax a bit, and chill out a few hours at my hotel, before travelling home to Linköping again.

Picture of me at the dinner on Oct 14, in the evening. I didn’t have a lecture then, but this picture gives a feeling for the scale of the event, and the size of the big stage: it probably featured 500+ participants.



Health Hub – Make Sweden number one healthy country in Europe

Events, News Posted on Sat, October 25, 2025 21:19:38

Health Hub – a room full of visionaries on a mission: Make Sweden number one healthy country in Europe.

  • AI twins that show you what your health will look like in 20 years with your current lifestyle and inspire you to make change now – presented by Gunnar Cedersund and Johan Holmsäter.
  • How you frame your experience may be your number one ticket to better health: Rather than focusing on “I’m reducing these unhelpful habits” focus on “I’m magnifying these helpful and enjoyable habits”.
  • Every single movement during the day counts.
  • Daily movement, rest, diet, sleep: Four pillars of good health. All four connected. None of them can be compromised.
  • Employee health should be a vital business goal, not a good-to-have or a temporary effort.
  • It is never too late to become healthy.

While popular trends in health come and go, one thing is alarming: We have never had so much information about health and yet we have never been so unhealthy. We have well-tested theories. What we need are applied, pragmatic solutions to health problems we are facing. We must start thinking in terms of preventive healthcare. This was the conclusion. Everyone left them room with an intention to carry the torch for making preventive healthcare a reality.

Gunnar Cedersund and Johan Holmsäter, standing in front of the audience, are presenting how medical digital twins can be (and is being) used for preventive healthcare.
Gunnar Cedersund and Johan Holmsäter presenting how medical digital twins can be (and are being) used for preventive healthcare.


Presentations in Stockholm next week – Health HUB, with Johan Holmsäter

Events, Uncategorised Posted on Sat, October 11, 2025 19:25:58

Next week, I will be in Stockholm to give presentations at some different events. First out is Health HUB, arranged by HOLISTAL, and focusing on preventive health. I am giving this presentation together with the health guru Johan Holmsäter, who – among many other things – founded Friskis & Svettis (half a million members!), back in the early 1980s. Since then, he has done many things, and one of them is corporate health. In this, he has many examples of turning around high rates of sick leave (e.g. 8% to 2%) by utilizing some of his various health programs. In the last 1-2 years, Johan, our spinoff company SUND, and a few others have jointly founded a new company – Lev Skönare – which now are rolling out a joint product: his health programs empowered by our digital twins. In this joint presentation, you will hear about both of our personal and professional journeys, as well as about the health journey “Hälsoresan”, which our customer Norlandia is about to embark upon next week.

Later in the week, on Wednesday, I will give a presentation at the event Cambio Connect. More info about that in a separate video and blog post, to be posted shortly.



Maria-Anna Sotiropoulou – New contact person for STRATIF-AI

News Posted on Sat, September 27, 2025 22:21:15
Maria-Anna Sotiropoulou

We have the pleasure to announce that Maria-Anna Sotiropoulou will be the new contact person for STRATIF-AI.

STRATIF-AI is our flagship project to improve prevention, treatment, and rehabilitation of stroke patients using digital twins and AI. STRATIF-AI has received funding over four years by Horizon Europe, the EU’s key funding programme for research and innovation.

Read more about STRATIF-AI on its homepage

Maria-Anna holds a B.Sc. in Computer Science and Biomedical Informatics and an M.Sc. in Protein Biotechnology. She is currently a Research Assistant at Linköping’s University Department of Biomedical Engineering (IMT), working in the Integrative Systems Biology Group. Her research interests include developing advanced modeling tools for studying intracellular metabolic changes in neurodegenerative diseases, as well as cancer-neuron modeling. She has experience in both experimental and computational research, which complements her interdisciplinary background.

For any administrative inquiries related to STRATIF-AI, from now on, please reach out to both the coordinator, Gunnar Cedersund, and Maria-Anna.



New findings by the ISB Group challenge modern interpretation of fMRI BOLD signals

News Posted on Wed, September 17, 2025 10:02:12

Functional magnetic resonance imaging (fMRI) is one of the most powerful tools in neuroscience, but what does the measured signal really reflect? Traditionally, the fMRI signal has been assumed to mainly reflect excitatory neuron activity. However, recent findings by Nicholas Sundqvist and Henrik Podéus of the ISB Group suggest that inhibitory interneurons play a much more significant role.

Using a model-driven meta-analysis approach, we analysed data across several different studies, revealing that:

  • Less than 20% of the fMRI BOLD signal comes from excitatory neurons
  • A dominant 50–80% arises from inhibitory interneurons

Our model offers a unified mechanistic explanation for why fMRI responses sometimes appear contradictory across experiments. For example, the model provides a plausible mechanism that result in a biphasic vascular response that emerge only under high intensity stimulation.

Taken together, these results point towards a new consensus view: inhibitory interneurons, not excitatory neurons, are the primary drivers of fMRI signals.

We have recently published a manuscript about these findings in the journal Computers in Medicine and Biology – a leading publication in computational biology and medical informatics.



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